Ethanol-mediated alterations in oligodendrocyte differentiation in the developing brain.

CONCLUSION: Prenatal EtOH exposure is associated with excessive OL apoptosis and/or delayed OL maturation in human fetal brain. This is accompanied by markedly dysregulated expression of several chemokines and cytokines, in a pattern predictive of increased OL cytotoxicity and reduced OL differentiation. These findings are consistent with findings in animal models of FAS.
PMID: 33189883 [PubMed - as supplied by publisher]

Source: Neurobiology of Disease - November 12, 2020 Category: Neurology Authors: Darbinian N, Darbinyan A, Merabova N, Bajwa A, Tatevosian G, Martirosyan D, Zhao H, Selzer ME, Goetzl L Tags: Neurobiol Dis Source Type: research