Recent development of novel HDAC6 isoform-selective inhibitors.

Recent development of novel HDAC6 isoform-selective inhibitors.
Curr Med Chem. 2020 Nov 11;:
Authors: Zhao Y, Liang T, Hou X, Fang H
Abstract
As an important posttranscription modification, histone deacetylation plays significant roles in chromatin remodeling and gene expression. The aberrant modification of histone deacetylation leads to various diseases. As a critical member of histone deacetylase (HDAC), HDAC6 serves as a key modulator in many physiological processes. Abnormal expression of HDAC6 gives rise to cancer, neurodegeneration and other diseases. Here, we reviewed recent advances in physiological, protein structure and development of HDAC6 selective inhibitors.
PMID: 33176627 [PubMed - as supplied by publisher]

Source: Current Medicinal Chemistry - November 11, 2020 Category: Chemistry Authors: Zhao Y, Liang T, Hou X, Fang H Tags: Curr Med Chem Source Type: research