Role of exosome in autoimmunity, with a particular emphasis on rheumatoid arthritis

AbstractCell ‐derived exosomes are identified as carriers of lipids, proteins, and genetic materials that participate in cell‐cell signal communication, biological process, and cell signaling. Also, their involvement has been reported in a vast array of disorders and inflammatory conditions such as autoimmun e diseases. Rheumatoid arthritis (RA), a common cause of joint disorder, is an inflammation‐based disease in which the precise understanding of its pathogenesis needs to be further investigated. Also, there is only a palliative care approach for the alleviation of RA symptoms. This paper discusses the recent advances in the biology of exosomes in autoimmune disorders especially in RA, and also provides a new line of research for arthritis therapy using exosomes.
Source: International Journal of Rheumatic Diseases - Category: Rheumatology Authors: Tags: REVIEW Source Type: research