Molecular profile of H ürthle cell carcinomas: recurrent mutations in the Wnt/β-catenin pathway.

Conclusions: This series of HCC presents a wide range of mutations in the Wnt/β-catenin, MAPK and PI3K-AKT-mTOR pathways. The recurrent involvement of Wnt/β-catenin pathway, particularly mutations in APC and FAT1, are of particular interest. The data suggest that mutated FAT1 may represent a potential novel driver in HCC tumorigenesis and that the Wnt/β-catenin pathway plays a critical role in this distinct thyroid malignancy.
PMID: 33120354 [PubMed - in process]

Source: European Journal of Endocrinology - October 31, 2020 Category: Endocrinology Authors: Santana NO, Lerario AM, Schmerling CK, Marui S, Alves VAF, Hoff AO, Kopp P, Danilovic DLS Tags: Eur J Endocrinol Source Type: research