Mechanical ventilation in Guillain-Barr é syndrome.

Mechanical ventilation in Guillain-Barré syndrome. Expert Rev Clin Immunol. 2020 Oct 28;: Authors: Shang P, Zhu M, Baker M, Feng J, Zhou C, Zhang HL Abstract INTRODUCTION: Up to 30% of patients with Guillain-Barré syndrome (GBS) develop respiratory failure requiring intensive care unit (ICU) admission and mechanical ventilation. Progressive weakness of the respiratory muscles is the leading cause of acute respiratory distress and respiratory failure with hypoxia and hypercarbia. Bulbar weakness may compromise airway patency and predispose patients to aspiration pneumonia. Mechanical ventilation is often necessary for patients with severe GBS. All references were selected from PubMed, Google Scholar, Cochrane database, and Web of Science; most were published between 2010 and 2020.Areas covered: Clinical questions related to the use of mechanical ventilation include but are not limited to: When to start? Invasive or non-invasive? When and how to wean? When to perform tracheostomy? Complications of GBS in the ICU including nosocomial infection, ventilator-associated pneumonia, and intensive care unit-acquired weakness may aggravate the disease and prolong mechanical ventilation and ICU stay. In this narrative review, the authors summarize the up-to-date knowledge of the incidence, pathophysiology, evaluation, and general management of respiratory failure in GBS. Expert opinion: Respiratory failure in GBS merits more attention from car...
Source: Expert Review of Clinical Immunology - Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research