Scutellarin is Highly Likely to be Responsible for Drug-Drug Interactions Mediated by Hepatic Organic Anion-Transporting Polypeptide1B3

ConclusionScutellarin may inhibit the hOATP1B3- and rOATP1B2-mediated transport of rosuvastatinin vitro, and exerts a moderate inhibitory effect on the pharmacokinetics of rosuvastatin in rats. Scutellarin is highly likely to participate in drug-drug interactions, as mediated by OATP1B3 in humans.

Source: Pharmaceutical Research - October 29, 2020 Category: Drugs & Pharmacology Source Type: research