Management and evaluation of sodium [131I] iodide contamination after oral administration

Radioiodine therapy using oral administration of Iodine-131 (131I) is a widespread employed strategy for the treatment of hyperthyroidism and thyroid cancer. Such a therapy requires well-trained staff, equipment and procedures regarding radiation safety. The aims of this work are to report an incidental experience of radioprotection with a 370 MBq sodium [131I] iodide capsule, which arose following vomiting one minute after the oral administration in a nuclear medicine department and assessment of capsule leakage in a stomach like environment by in vitro experiment. Measurements of the radiation dose rate at the different steps of the decontamination procedure were performed and management of the situation described. Dose rate in vomit was 113 µSv/h [directional dose equivalent H’(0.07)] after capsule withdrawal and was decreased by 10 times after the first decontamination attempt. To evaluate the 131I release following administration to the patient, an in vitro experiment was designed to recap capsules degradation in a stomach like environment including acidic solution (pH 1) and temperature at 35–37°c. A significant release of 131I (
Source: Nuclear Medicine Communications - Category: Nuclear Medicine Tags: Technical Note Source Type: research