Resveratrol enhances apoptosis induced by the heterocyclic aromatic amines in p53-wt LoVo cells, but not in p53-deficient HaCaT cells.

Resveratrol enhances apoptosis induced by the heterocyclic aromatic amines in p53-wt LoVo cells, but not in p53-deficient HaCaT cells.
Acta Biochim Pol. 2020 Oct 27;:
Authors: Kuryłowicz K, Cierniak A, Madej E, Skalniak Ł, Wolnicka-Głubisz A
Abstract
In the present study, we investigated the influence of resveratrol on PhIP treated human colon cancer cells and compared the effect to HaCaT cells considered as normal, human keratinocytes. Our results show that resveratrol decreases DNA damage in both cell types, it increases the sensitivity of LoVo cells to apoptosis and has no effect on PhIP-treated HaCaT cells. We confirm that PhIP-induced apoptosis is p53 and caspase 3/7 dependent. Interestingly, normal cells such as HaCaT, which lack functional p53 are more resistant to PhIP treatment.
PMID: 33108147 [PubMed - as supplied by publisher]

Source: Acta Biochim Pol - October 27, 2020 Category: Biochemistry Authors: Kuryłowicz K, Cierniak A, Madej E, Skalniak Ł, Wolnicka-Głubisz A Tags: Acta Biochim Pol Source Type: research