Mechanistic differences underlying HIV latency in the gut and blood contribute to differential responses to latency-reversing agents

Conclusion: The gut harbors HIV-infected cells in a latent-like state that can be reversed by T-cell activation involving CD3/CD28 signaling. Histone deacetylation and protein kinase B may contribute less to HIV transcriptional initiation in the gut, whereas protein kinase C may contribute more. New LRAs or combinations are needed to induce multiply-spliced HIV and should be tested on both blood and gut.
Source: AIDS - Category: Infectious Diseases Tags: BASIC SCIENCE Source Type: research