19.3 developmental exposure to near-roadway pollution produces behavioral and histological phenotypes relevant to neurodevelopmental disorders

Epidemiological studies consistently implicate traffic-related air pollution (TRAP) and/or proximity to heavily trafficked roads as risk factors for developmental delays and neurodevelopmental disorders (NDDs); however, there are limited preclinical data demonstrating a causal relationship. To test the effects of TRAP, pregnant rat dams were transported to a vivarium adjacent to a major freeway tunnel system in Northern California where they were exposed to TRAP drawn directly from the tunnel or filtered air (FA).
Source: Journal of the American Academy of Child and Adolescent Psychiatry - Category: Psychiatry Authors: Tags: Symposium 19 Source Type: research