19.3 developmental exposure to near-roadway pollution produces behavioral and histological phenotypes relevant to neurodevelopmental disorders
Epidemiological studies consistently implicate traffic-related air pollution (TRAP) and/or proximity to heavily trafficked roads as risk factors for developmental delays and neurodevelopmental disorders (NDDs); however, there are limited preclinical data demonstrating a causal relationship. To test the effects of TRAP, pregnant rat dams were transported to a vivarium adjacent to a major freeway tunnel system in Northern California where they were exposed to TRAP drawn directly from the tunnel or filtered air (FA).
Source: Journal of the American Academy of Child and Adolescent Psychiatry - Category: Psychiatry Authors: Jill L. Silverman, Elizabeth L. Berg, Kelley T. Patten, Anthony E. Valenzuela, Christopher Wallis, Janine M. LaSalle, Annie Vogel Ciernia, Keith J. Bein, Anthony S. Wexler, Pamela J. Lein Tags: Symposium 19 Source Type: research
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