Repair of radiation damage of U2OS osteosarcoma cells is related to DNA-dependent protein kinase catalytic subunit (DNA-PKcs) activity.

In conclusion, DNA-PKcs siRNA might have a potential for osteosarcoma treatment by sensitizing osteosarcoma cells to γ-ray through modulation on oxidative stress-mediated DNA DSBs repair and mitochondrial pathway apoptosis.
PMID: 24390088 [PubMed - as supplied by publisher]

Source: Molecular and Cellular Biochemistry - January 5, 2014 Category: Biochemistry Authors: Tang X, Yuan F, Guo K Tags: Mol Cell Biochem Source Type: research