Disparate effects of metformin on Mycobacterium tuberculosis infection in diabetic and non-diabetic mice.

Disparate effects of metformin on Mycobacterium tuberculosis infection in diabetic and non-diabetic mice.
Antimicrob Agents Chemother. 2020 Oct 12;:
Authors: Sathkumara HD, Hansen K, Miranda-Hernandez S, Govan B, Rush CM, Henning L, Ketheesan N, Kupz A
Abstract
Comorbid type 2 diabetes poses a great challenge to the global control of tuberculosis. Here we assessed the efficacy of metformin (MET); an anti-diabetic drug, in mice infected with a very-low dose of Mycobacterium tuberculosis In contrast to diabetic mice, infected non-diabetic mice that received the same therapeutic concentration of MET presented with significantly higher disease burden. This warrants further studies to investigate the disparate efficacy of MET against tuberculosis in diabetic and non-diabetic individuals.
PMID: 33046495 [PubMed - as supplied by publisher]

Source: Antimicrobial Agents and Chemotherapy - October 12, 2020 Category: Microbiology Authors: Sathkumara HD, Hansen K, Miranda-Hernandez S, Govan B, Rush CM, Henning L, Ketheesan N, Kupz A Tags: Antimicrob Agents Chemother Source Type: research