Protection induced by estradiol benzoate in the MPP+ rat model of Parkinson's disease is associated with the regulation of the inflammatory cytokine profile in the nigro striatum

Previously, we have demonstrated that β-estradiol-3-benzoate (EB) has a protective effect on the neurodegenerative experimental model of Parkinson's disease. The protective effect is through the induction of the expression of paraoxonase-2 (PON2) in the striatum. PON2 has proven to have antioxidant and anti-inflammatory activity, this protein has a beneficial effect in MPP+ model in rats decreasing the lipid peroxidation and the oxidative stress. Furthermore, the molecular effect and the pathway by which EB induces protection were not further pursued.

Source: Journal of Neuroimmunology - October 14, 2020 Category: Allergy & Immunology Authors: Yoshajandith Aguirre-Vidal, Jorge Morales-Montor, Carmen T. G ómez de León, Pedro Ostoa-Saloma, Mariana Díaz-Zaragoza, Sergio Montes, Marcela Arteaga-Silva, Antonio Monroy-Noyola Source Type: research