Anti-SOX1 Antibodies in Paraneoplastic Neurological Syndrome.

In conclusion, the presence of anti-SOX1 abs alone is a potential predictor of an uncommon paraneoplastic neurological disorder, usually occurring in the setting of LEMS, PCD, and SCLC. The detection of anti-SOX1 abs contributes to an early diagnosis of underlying tumors, given the diversity of clinical symptoms and the absence of characteristic neuroimaging features. PMID: 33029958 [PubMed]
Source: Journal of Clinical Neurology - Category: Neurology Tags: J Clin Neurol Source Type: research

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Paraneoplastic neurological syndromes (PNS) are rare disorders affecting any part of the central, peripheral or autonomic nervous system that occur in association with cancer. Among cancer patients, less than 1% overall develop PNS. Anti ‐SOX1 antibodies' positive paraneoplastic neurological disorders are rare and are usually associated with small cell lung cancer (SCLC). Here, we report a case of a 61‐year‐old male patient who presented with an unusual anti‐SOX1 positive PNS. The right tibialis anterior showed noticeable lo w‐amplitude motor unit potentials and high amplitude motor potentials in electrodiagnosti...
Source: Thoracic Cancer - Category: Cancer & Oncology Authors: Tags: CASE REPORT Source Type: research
Publication date: Available online 6 May 2019Source: Journal of Clinical NeuroscienceAuthor(s): Yiqi Liu, Jianying Xi, Lei Zhou, Hui Wu, Dongyue Yue, Wenhua Zhu, Jie Lin, Jiahong Lu, Chongbo Zhao, Kai QiaoAbstractIn order to describe the clinical characteristics, treatment response and long-term follow up in Lambert–Eaton myasthenic syndrome (LEMS) patients with and without small cell lung cancer (SCLC) in East China, patients seen in Huashan Hospital from January 1997 to December 2017 were included. Clinical information was collected retrospectively and quantitative MG (QMG) score, manual muscle testing (MMT), activ...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
Antibodies to SOXB1 proteins in patients with paraneoplastic disorders are associated with small-cell lung cancer (SCLC), particularly in Lambert-Eaton myasthenic syndrome (LEMS). We aimed to establish if SOX2 antibodies could be used to identify SCLC and other tumours found in a range of paraneoplastic disorders and controls.SOX2 antibodies were detectable in 61% of patients with LEMS-SCLC, and in other paraneoplastic disorders, such as opsoclonus-myoclonus and paraneoplastic cerebellar degeneration, only when there was an underlying SCLC.
Source: Journal of Neuroimmunology - Category: Allergy & Immunology Authors: Source Type: research
Clinical case reports can be powerful and informative; they can suggest novel hypotheses, identify gaps of knowledge, and provide suggestions for improvement. In this issue of Neurology® Neuroimmunology &Neuroinflammation, Hottinger et al.1 report a fascinating case with interesting implications. The authors describe a 71-year-old woman with metastatic small-cell lung cancer (SCLC) who developed anti-Hu–associated paraneoplastic encephalitis 4 days after receiving treatment with immune checkpoint inhibitors (nivolumab and ipilimumab). Considering that this disorder is mediated by cytotoxic T cells against a f...
Source: Neurology Neuroimmunology and Neuroinflammation - Category: Neurology Authors: Tags: Editor ' s Corner Source Type: research
We report a 49 year old male, with over thirty pack years of smoking, who presented with dysautonomia, constitutional symptoms and weakness of all four limbs. Investigations confirmed axonal motor neuropathy with limited stage SCLC with fibro nodular lesions right upper lobe and mediastinal lymphadenopathy. He improved dramatically following chemotherapy and radiotherapy. PMID: 29313588 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
AbstractLambert –Eaton myasthenic syndrome (LEMS) is a rare autoimmune neuromuscular junction disorder that is related to the loss of functional P/Q-type voltage-gated calcium channels (VGCCs) on presynaptic nerve terminals. Up to 60% of cases occur as a paraneoplastic disorder (SCLC-LEMS), most commonly in assoc iation with small cell lung cancer. The remaining cases have an idiopathic non-tumor etiology but are associated with underlying autoimmune disease (NT-LEMS). Patients with LEMS invariably experience progressive proximal muscle weakness, often accompanied by general fatigue and autonomic symptoms. S ome LEMS...
Source: Journal of Neurology - Category: Neurology Source Type: research
Conclusions: Improved SCLC tumor survival seen in patients with LEMS and SCLC may not be due solely to lead time bias, given that survival advantage remains after allowing for other prognostic factors and that the same degree of survival advantage is not seen in patients with paraneoplastic neurologic syndromes other than LEMS presenting before SCLC diagnosis.
Source: Neurology - Category: Neurology Authors: Tags: Lambert-Eaton syndrome, Paraneoplastic syndrome ARTICLE Source Type: research
Anti-SOX1 antibodies are associated with small cell lung cancer (SCLC) and predict a paraneoplastic etiology in Lambert-Eaton myasthenic syndrome (LEMS). In 2010, a study described these antibodies in a small cohort of putative non-paraneoplastic, immune-mediated neuropathies. In this respect, we investigated the seroprevalence and specificity of anti-SOX1 antibodies in a large cohort of neurological disorders.
Source: Journal of the Neurological Sciences - Category: Neurology Authors: Source Type: research
We report a patient who had a recurrence of both SCLC and LEMS after a 13-year DFS period. A 69-year-old man was diagnosed with LEMS and SCLC (cT0N2M0, stage IIIA) 13 years ago. Chemoradiotherapy was performed and a complete response was achieved. With anticancer treatment, the LEMS symptoms was alleviated. At the age of 82 years, gait disturbance appeared followed by left supraclavicular lymphadenopathy and further examination revealed the recurrence of SCLC. Careful screening for the recurrence of SCLC might be needed when the patient has recurrent or secondary paraneoplastic neurological syndrome even after a ...
Source: Chinese Journal of Cancer - Category: Cancer & Oncology Tags: Chin J Cancer Source Type: research
Abstract Paraneoplastic neurological syndromes (PNS) are defined as all non‐metastatic neurological complications of cancer in which no other etiologies, such as vascular, infectious or metabolic, were determined. Recently, Sry‐like high‐mobility group box (SOX1) antibody associated with PNS has been described, and is associated with Lambert–Eaton myasthenic syndrome, paraneoplastic cerebellar degeneration and paraneoplastic peripheral neuropathy invariably in the background of underlying small‐cell lung cancer. A 75‐year‐old man was admitted to our neurology clinic at Hacettepe University Hospital, Sihhi...
Source: Clinical and Experimental Neuroimmunology - Category: Neurology Authors: Tags: Case Report Source Type: research
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