Metformin reverses the drug resistance of cisplatin in irradiated CNE-1 human nasopharyngeal carcinoma cells through PECAM-1 mediated MRPs down-regulation.

Conclusions: Metformin, due to its independent effects on PECAM-1, had a unique anti-proliferative effect on irradiated CNE-1 cells. It would be a new therapeutic option to conquer cisplatin resistance for advanced NPC patients after radiotherapy.
PMID: 33029084 [PubMed - in process]

Source: International Journal of Medical Sciences - October 9, 2020 Category: Biomedical Science Tags: Int J Med Sci Source Type: research