In-silico Molecular Interaction of Short Synthetic Lipopeptide/Importinalpha and In-vitro Evaluation of Transgene Expression Mediated by Liposome-Based Gene Carrier.

CONCLUSION: Our study for the first time has shown that the fully synthesized short lipopeptide Pal-CKKHH is able to interact firmly with the Importin-α he lipopeptide is able to condense DNA molecules efficiently, facilitate transgene expression, expedite nuclear uptake process, and hence has the characteristics of a potential transfection agent. PMID: 33019928 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/33019928?dopt=Abstract

Source: Current Gene Therapy - October 3, 2020 Category: Genetics & Stem Cells Authors: Tarwadi T, Jazayeri JA, Pambudi S, Arbianto AD, Rachmawati H, Kartasasmita RE, Asyarie S Tags: Curr Gene Ther Source Type: research