Chelicerata sDscam isoforms combine homophilic specificities to define unique cell recognition [Biochemistry]

Thousands of Down syndrome cell adhesion molecule (Dscam1) isoforms and ∼60 clustered protocadhrein (cPcdh) proteins are required for establishing neural circuits in insects and vertebrates, respectively. The strict homophilic specificity exhibited by these proteins has been extensively studied and is thought to be critical for their function in neuronal self-avoidance....

Source: Proceedings of the National Academy of Sciences - October 5, 2020 Category: Science Authors: Fengyan Zhou, Guozheng Cao, Songjun Dai, Guo Li, Hao Li, Zhu Ding, Shouqing Hou, Bingbing Xu, Wendong You, Gil Wiseglass, Feng Shi, Xiaofeng Yang, Rotem Rubinstein, Yongfeng Jin Tags: Biological Sciences Source Type: research