Attenuated measles virus overcomes radio ‑ and chemoresistance in human breast cancer cells by inhibiting the non‑homologous end joining pathway.

Attenuated measles virus overcomes radio‑ and chemoresistance in human breast cancer cells by inhibiting the non‑homologous end joining pathway. Oncol Rep. 2020 Nov;44(5):2253-2264 Authors: Yang B, Shi J, Sun Z, Zhu D, Xu X Abstract Breast cancer is the most commonly diagnosed cancer and is the second leading cause of death in women. However, resistance to radio‑ and chemotherapy remains one of the major difficulties in the treatment of breast cancer. Therefore, the aim of the present study was to identify novel regimens to overcome treatment resistance in patients with breast cancer. The results of the present study demonstrated that the attenuated Edmonston‑B vaccine strain of the measles virus (MV‑Edm) significantly re‑sensitized breast cancer cells to doxorubicin and ionizing radiation. Mechanistically, MV‑Edm reduced DNA double strand repair efficiency by decreasing the mRNA and protein expression levels of p53‑binding protein 1 and disassembling the non‑homologous end joining (NHEJ) complex. NHEJ deficiency, which was achieved using DNA ligase IV knockout via CRISPR/Cas9, resulted in failure to overcome resistance mediated by MV‑Edm infection. As a result of the significant synergy between attenuated MV and radio‑ or chemotherapy, MV‑Edm provides a novel strategy for the treatment of radio‑ and chemoresistant breast cancer. PMID: 33000219 [PubMed - in process]
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

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Conditions:   Anatomic Stage IV Breast Cancer AJCC v8;   Invasive Breast Carcinoma;   Metastatic Breast Adenocarcinoma;   Prognostic Stage IV Breast Cancer AJCC v8;   Recurrent Breast Carcinoma Intervention:   Biological: Oncolytic Measles Virus Encoding Helicobacter pylori Neutrophil-activating Protein Sponsors:   Mayo Clinic;   National Cancer Institute (NCI) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusion: MeV vaccine is useful and safe as anticancer therapy with a notable impact on the local Iraqi breast cancer AMJ13 cells.
Source: Saudi Journal of Biological Sciences - Category: Biology Source Type: research
Poshmaal Dhar1 and Julie McAuley2* 1Faculty of Health, School of Medicine, Deakin University, Geelong, VIC, Australia 2Department of Microbiology and Immunology, Peter Doherty Institute, University of Melbourne, Melbourne, VIC, Australia The family of cell surface (cs-) mucins are constitutively expressed at the cell surface by nearly all epithelial cells, beneath the gel-mucin layer. All cs-mucin family members have structural features that enable them to act as a releasable decoy barrier to mucosal pathogens, by providing ligands for pathogen binding and the ability to shed the bound extracellular domain. Due ...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Conclusion: The incidence rate of non-communicable diseases increased over the decade and was associated with increased mortality and disability, reduced quality of life, and increased health-care costs, indicating an urgent need to establish prevention and control programs. The rising trend in the incidence of cancers may also become a health care issue in Saudi Arabia in the coming years. PMID: 30834424 [PubMed - in process]
Source: Saudi Medical Journal - Category: Middle East Health Tags: Saudi Med J Source Type: research
In this study, we show that calorie restriction is protective against age-related increases in senescence and microglia activation and pro-inflammatory cytokine expression in an animal model of aging. Further, these protective effects mitigated age-related decline in neuroblast and neuronal production, and enhanced olfactory memory performance, a behavioral index of neurogenesis in the SVZ. Our results support the concept that calorie restriction might be an effective anti-aging intervention in the context of healthy brain aging. Greater Modest Activity in Late Life Correlates with Lower Incidence of Dementia ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Geetanjali Lal, Maitreyi S. Rajala
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Beloved Hollywood celebrities, famous politicians or members of the British royal family: no better advertisement for fitness tracker producers and health tech companies. As models, actors and actresses are highly influential people, their early adoption of digital solutions could also push the masses towards living more healthily with technologies. On the other hand, celebrities are inclined to follow questionable health trends, too, which go against decades of medical evidence. Those examples, everyone should rather reject. Wearables conquered Hollywood, the White House, and the British royal family Celebrities are all a...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Social media in Healthcare celebrities digital health digital technologies digital technology famous fitness future health influencer health influencers Hollywood trackers trends wearables wellness Source Type: blogs
As a pharmacist, Kathy James considers herself well educated about the importance of getting regular cancer screenings. Even though the 55-year-old had no history of cancer in her family, she never skipped her regular mammograms, and she gave herself regular breast exams. So she was dumbfounded when, during one of those self-exams in May 2017, she felt a marble-size lump in her left breast. A visit to the doctor confirmed it. “The radiologist came in with his hands in his pockets and looked down and said, ‘It doesn’t look good,'” James says. After a biopsy, James and her husband learned she had meta...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized breast cancer news Frontiers of Medicine Source Type: news
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