Methylation-mediated LINC00261 suppresses pancreatic cancer progression by epigenetically inhibiting c-Myc transcription

Conclusions: Our findings indicate that methylation-mediated LINC00261 suppresses PC progression by epigenetically repressing c-Myc expression. These findings expand the therapeutic potential of LINC00261, possibly providing evidence to support the development of epigenetic drugs or therapeutic strategies. This research adds further insights into the etiology of PC and indicates that LINC00261 may be a prognostic and therapeutic target in PC.

Source: Theranostics - October 3, 2020 Category: Molecular Biology Authors: Songsong Liu, Yao Zheng, Yujun Zhang, Junfeng Zhang, Fuming Xie, Shixiang Guo, Jianyou Gu, Jiali Yang, Ping Zheng, Jiejuan Lai, Liangyu Yin, Huaizhi Wang Tags: Research Paper Source Type: research