Cardiac malformations in children with congenital hypothyroidism.

Cardiac malformations in children with congenital hypothyroidism. J Biol Regul Homeost Agents. 2020 Jul-Aug;34(4 Suppl. 2):91-97 Authors: SPECIAL ISSUE: FOCUS ON PEDIATRIC CARDIOLOGY, Scavone M, Tallarico V, Stefanelli E, Parisi F, De Sarro R, Salpietro C, Ceravolo G, Sestito S, Pensabene L, Chimenz R, Calabrò MP, Gitto E, Giancotti L, Concolino D Abstract Congenital hypothyroidism (CH) is the most common endocrine disease in children, according to literature, infants with CH have an increased risk of associated congenital malformations (CM), especially cardiac defects (CD), compared to the general population. We retrospectively analyzed medical records of 255 patients with a positive screening result for CH in the period 1991-2016 followed at our Center. At the time of enrollment, the clinical examination included looking for the presence of heart murmurs and dysmorphic features. In all patients an echocardiography with cardiological evaluation were performed. Of all patients, 191 were included in the final analysis. Of these, 51.3% (98/191) presented an eutopic normally sized thyroid gland while 48.7% (93/191) showed a thyroid dysgenesis. Among the studied infants, 13.6% (26/191) presented CD. The most frequent cardiac anomaly was atrial septal defect (ASD) which was found in 65.4% (17/26) of patients with CD. Other defects were ventricular septal defect (VSD), patent ductus arteriosus (PDA), pulmonary valve stenosis (PvS), transp...
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research