The Origin of Ovarian Cancer Species and Precancerous Landscape

Unlike other human cancers, in which all primary tumors arise de novo, ovarian epithelial cancers are primarily imported from either endometrial or fallopian tube epithelium. The prevailing paradigm in the genesis of high-grade serous carcinoma (HGSC), the most common ovarian cancer, posits development in fallopian tubes through stepwise tumor progression. In recent years, progress has been made not only in gathering terabytes of omics data but also in detailing the histologic-molecular correlations required to look into and make sense of the tissue origin of HGSC.
Source: American Journal of Pathology - Category: Pathology Authors: Tags: Review Source Type: research