Lower CSF Homovanillic Acid Relates to Higher Burden of Neuroinflammation and Depression in People with HIV Disease.

CONCLUSIONS: Results suggest that the pathophysiology of depression in PWH differs from that in HIV- individuals. Specifically, lower central dopaminergic activity was selectively associated with greater depressive symptoms and neuroinflammation in PWH. With the rise in consideration of DA agonists for the treatment of depression, these results suggest that PWH may show a greater response to these agents than their HIV- peers. PMID: 32966871 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32966871?dopt=Abstract

Source: Brain, Behavior, and Immunity - September 19, 2020 Category: Neurology Authors: Saloner R, Cherner M, Grelotti DJ, Paolillo EW, Moore DJ, Heaton RK, Letendre SL, Kumar A, Grant I, Ellis RJ Tags: Brain Behav Immun Source Type: research