Delving into Early Onset Pancreatic Ductal Adenocarcinoma: How Does Age Fit In?

CONCLUSIONS: Our comprehensive analysis of sequencing data generated from a large cohort of PDAC patient samples highlights a distinctive pattern of bi-allelic CDKN2A mutation in EOPC tumors. Increased expression of FOXC2 in EOPC, with the correlation between FOXC2 and EMT pathways, represent novel molecular characteristics of EOPC.
PMID: 32958704 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - September 20, 2020 Category: Cancer & Oncology Authors: Tsang ES, Topham JT, Karasinska JM, Lee MK, Williamson LM, Mendis S, Denroche RE, Jang GH, Kalloger SE, Moore RA, Mungall AJ, Bathe OF, Tang PA, Notta F, Wilson JM, Laskin J, O'Kane GM, Knox JJ, Goodwin RA, Loree JM, Jones SJ, Marra MA, Gallinger S, Schae Tags: Clin Cancer Res Source Type: research