Efficacy of delayed administration of sargramostim up to 120 hours post exposure in a nonhuman primate total body radiation model.
CONCLUSION: In a NHP ARS model, sargramostim administered starting at 48 h post-radiation was effective to improve survival, while beneficial hematological effects were observed with sargramostim initiated up to 120 h post exposure. PMID: 32960660 [PubMed - as supplied by publisher]
Authors: Hammerschlag MR, Sharma R Abstract INTRODUCTION: Azithromycin was recommended as the first-line therapeutic regimen for treatment of genital infections in men and women by the Centers for Disease Control in 1998. A series of studies of azithromycin for treatment of rectal chlamydial infection in men who have sex with men (MSM) found that azithromycin was significantly less effective than doxycycline. AREAS COVERED: Literature on treatment of rectal C. trachomatis from 2000 through May 2020 was searched using PubMed. Retrospective and observational studies were identified documenting the frequency and t...
Publication date: October 2020Source: Brain, Behavior, and Immunity, Volume 89Author(s): Mario Gennaro Mazza, Rebecca De Lorenzo, Caterina Conte, Sara Poletti, Benedetta Vai, Irene Bollettini, Elisa Maria Teresa Melloni, Roberto Furlan, Fabio Ciceri, Patrizia Rovere-Querini, COVID-19 BioB Outpatient Clinic Study group, Francesco Benedetti
Publication date: October 2020Source: Brain, Behavior, and Immunity, Volume 89Author(s): Xiaoqin Liu, Trine Munk-Olsen, Clara Albiñana, Bjarni J. Vilhjálmsson, Emil M. Pedersen, Vivi Schlünssen, Marie Bækvad-Hansen, Jonas Bybjerg-Grauholm, Merete Nordentoft, Anders D. Børglum, Thomas Werge, David M. Hougaard, Preben B. Mortensen, Esben Agerbo
Treatment of debilitating anxiety, depression, delirium, or psychosis with psychotropic medications for symptomatic and syndromic relief during complex medical treatment may be necessary to assist medically ill children through difficult or prolonged medical treatments. Antipsychotic medications often are used by pediatric psychiatric consultation-liaison (CL) psychiatrists. Drug-drug interactions, elevated liver enzymes, pancytopenia, and cardiac arrhythmias during a developmentally sensitive period are some of the factors considered by CL psychiatrists.
No abstract available
Based on clinical Camitta criteria, acquired aplastic anemia is categorized according to the degree of blood count depression as severe (sAA) or moderate (mAA). In some cases mAA is a precursor of sAA; in others it is a pathophysiologically distinct chronic non-progressive entity (chronic mAA (cmAA)). It is also possible that some seemingly mAA cases represent entities ranging from congenital bone marrow failure syndromes or hypocellular MDS to misdiagnosed systemic conditions with secondary aplasias. Discriminating true cmAA from these may be important for clinical management and requires prolonged observation.We have bee...
This report describes a dog infected with Hepatozoon canis, the first canine infection in the Republic of Korea. A 2-year-old intact male Maltese dog presented with anorexia and depression. Physical examinations revealed mild dehydration and hyperthermia (39.8°C), and blood analysis showed pancytopenia. Diff-Quik staining of blood smear specimens showed the presence of ellipsoidal shaped structures (gamonts of H. canis) within a small number of neutrophils. Real-time PCR analysis using whole blood confirmed infection by H. canis. The clinical condition of the dog improved after symptomatic treatment and administration ...
This study suggests that active and modifiable disease processes might be ongoing in patients with mild to moderate, persistent asthma receiving ICS. Although the lung function improvement observed does not warrant use of benralizumab in this population because it did not reach the minimum clinically important difference of 10%, further studies to assess this finding should be considered. Funding AstraZeneca.
Melissa L. Kelly, Angie N. Pinto, Dan Suan, Debbie Marriott, David A. Cooper, Sarah L. Pett This case report highlights the challenges of diagnosis, monitoring and treatment in a visceral leishmaniasis and HIV co-infected patient. This patient developed multiple complications including renal and liver failure, pancytopenia with recurrent sepsis as well as anal cancer, depression and poor quality of life. Urgent research specific to this cohort is needed, with an emphasis on accessible and affordable treatment options.