Physical exercise and 5-hydroxytryptophan, a precursor for serotonin synthesis, reduce penicillin-induced epileptiform activity.

CONCLUSIONS: It was determined that exercise reduced the spike number and delayed seizure significantly by potentiating the effect of 5-HTP. Given that 5-HTP used in combination with exercise can perform useful actions such as reducing seizure sensitivity and consequently improving the quality of life for individuals with epilepsy, it may be a potential candidate for the treatment of epilepsy in nonpharmacological methods. PMID: 32950765 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32950765?dopt=Abstract

Source: Epilepsy and Behaviour - September 16, 2020 Category: Neurology Authors: Kayacan Y, Ghojebeigloo BE, Çerit G, Kocacan SE, Ayyıldız M Tags: Epilepsy Behav Source Type: research