The Impact of Cryopreservation on Human Peripheral Blood Leukocyte Bioenergetics.

Conclusion: This study has demonstrated for the first time that cryopreservation of primary immune cells modified their metabolism in a time-dependent fashion, indicated by attenuated aerobic respiration and enhanced glycolytic activity. Taken together, we recommend caution in the interpretation of bioenergetic responses or BHI in cryopreserved samples.

Source: Clinical Science - January 19, 2015 Category: Biomedical Science Authors: K N. Keane, E K. Calton, V F. Cruzat, M J Soares, P Newsholme Source Type: research