Hypoxia-Mediated Regulation of Histone Demethylases Affects Angiogenesis-Associated Functions in Endothelial Cells.

CONCLUSIONS: Our study describes an additional level of epigenetic regulation where hypoxia induces redistribution of H3K27me3 around genes implicated in proliferation and angiogenesis. More specifically, we demonstrate that KDM4B and KDM6B play a key role in modulating the expression of the major angiogenic driver VEGFA. PMID: 32938217 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32938217?dopt=Abstract

Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 16, 2020 Category: Cardiology Authors: Hsin-Fu Liu O, Kiema M, Beter M, Ylä-Herttuala S, Laakkonen JP, Kaikkonen MU Tags: Arterioscler Thromb Vasc Biol Source Type: research