Oxidative Stress as a Therapeutic Target for the Prevention and Treatment of Early Age-related Macular Degeneration

Age-related macular degeneration (AMD) is the leading cause of irreversible visual loss among older adults in developed countries. It is a chronic, multifactorial, and progressive disease with the development of painless, central vision loss. Retinal pigment epithelial cell dysfunction is a core change in AMD that results from aging and the accumulated effects of genetic and environmental factors that, in part, is both caused by and leads to oxidative stress. In this review, we describe the role of oxidative stress, the cytoprotective oxidative stress pathways, and the impact of oxidative stress on critical cellular processes involved in AMD pathobiology.
Source: Survey of Ophthalmology - Category: Opthalmology Authors: Tags: Major review Source Type: research