HIF-1 α-induced up-regulation of microRNA-126 contributes to the effectiveness of exercise training on myocardial angiogenesis in myocardial infarction rats.

In conclusion, we revealed that HIF-1α, whose expression experiences up-regulation during ET, could function as an upstream regulator to miR-126, resulting in angiogenesis promotion through the PI3K/AKT/eNOS and MAPK signalling pathway and subsequent improvement of the MI heart function. PMID: 32939968 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32939968?dopt=Abstract

Source: J Cell Mol Med - September 15, 2020 Category: Molecular Biology Authors: Song W, Liang Q, Cai M, Tian Z Tags: J Cell Mol Med Source Type: research