B cell-activating factor (BAFF) in children with inflammatory bowel disease.

CONCLUSION: Faecal BAFF is a promising marker for monitoring the children with IBD, higher levels of BAFF being correlated with high CP. IMPACT: Faecal BAFF is a promising marker in monitoring the children with IBD, higher levels of BAFF being correlated with high faecal calprotectin.To our knowledge, this is the first paediatric study concerning BAFF evaluation in IBD.Faecal BAFF levels could be considered a potential non-invasive marker in monitoring IBD activity in paediatric population with clinically mild or inactive disease.Fig. 1Box plots of faecal BAFF concentration in the whole group with inflammatory bowel disease (IBD) and distinctly on Crohn's disease (CD) and ulcerative colitis (UC) groups compared with the control group.Fig. 2Box plots of serum BAFF concentration in the whole group with inflammatory bowel disease (IBD) and distinctly on Crohn's disease (CD) and ulcerative colitis (UC) groups compared with the control group.Fig. 3Correlation between faecal calprotectin and faecal BAFF in relation to the whole group of inflammatory bowel disease (IBD) (a), Crohn's disease (CD) (b) and ulcerative colitis (UC) (c). PMID: 32937648 [PubMed - as supplied by publisher]
Source: Pediatric Research - Category: Pediatrics Authors: Tags: Pediatr Res Source Type: research