Postoperative respiratory depression after hysterectomy.

Postoperative respiratory depression after hysterectomy. Bosn J Basic Med Sci. 2020 Sep 15;: Authors: L Laporta M, O Kinney M, R Schroeder D, Sprung J, Weingarten TN Abstract To investigate if sex-specific physiologic characteristics could impact postoperative respiratory depression risks in women, we studied incidence and risk factors associated with postoperative respiratory depression in a gynecologic surgical cohort. Only hysterectomies performed under general anesthesia from 2012 to 2017 were included to minimize interprocedural variability. Respiratory depression was defined as episodes of apnea, hypopnea, hypoxemia, pain-sedation mismatch, unplanned positive airway pressure device application, or naloxone administration in the post-anesthesia care unit. Multivariable logistic regression was used to explore the association with clinical characteristics. From 1,974 hysterectomies, 253 had postoperative respiratory depression, yielding an incidence of 128 (95% confidence interval, 114-144) per 1,000 surgeries. Risk factors associated with respiratory depression were older age (odds ratio 1.22 [95% confidence interval 1.02-1.46] per decade increase, p = 0.03), lower body weight (0.77 [0.62-0.94] per 10 kg/m2, p = 0.01), and higher intraoperative opioid dose (1.05 [1.01-1.09] per 10 mg oral morphine equivalents, p = 0.01); while sugammadex use was associated with a reduced risk (0.48 [0.30-0.75], p = 0.002). Respiratory depression ...
Source: Bosnian Journal of Basic Medical Sciences - Category: General Medicine Tags: Bosn J Basic Med Sci Source Type: research