High prevalence of subtle systolic and diastolic dysfunction in genotype-positive phenotype-negative relatives of dilated cardiomyopathy patients

The early diagnosis of genetically determined dilated cardiomyopathy (DCM) could improve the prognosis in mutation carriers. Left ventricular global longitudinal strain (LV GLS) and peak left atrial longitudinal strain (PALS) are promising techniques for the detection of subtle systolic and diastolic dysfunction. We sought to evaluate the prevalence of subtle systolic and diastolic dysfunction by LV GLS and PALS in a cohort of genotype-positive phenotype-negative (GPFN) DCM relatives.

Source: International Journal of Cardiology - September 15, 2020 Category: Cardiology Authors: Alessia Paldino, Giulia De Angelis, Matteo Dal Ferro, Giorgio Faganello, Aldostefano Porcari, Giulia Barbati, Renata Korcova, Piero Gentile, Jessica Artico, Antonio Cannat à, Marta Gigli, Bruno Pinamonti, Marco Merlo, Gianfranco Sinagra Source Type: research