Quinolizidine alkaloids from the roots of Sophora flavescens.

Quinolizidine alkaloids from the roots of Sophora flavescens. Nat Prod Res. 2020 Sep 14;:1-8 Authors: Li JC, Zhang ZJ, Liu D, Jiang MY, Li RT, Li HM Abstract Seventeen quinolizidine alkaloids, including a new matrine-type one, sophcence A (1), were isolated from the roots of Sophora flavescens Alt. The structure of compound 1 was elucidated by means of 1D and 2D NMR, as well as HR-ESI-MS spectroscopic data. The NMR data of (-)-Δ 7-dehydrosophoramine (10) and oxy-N-methylcytisine (12) were reported for the first time. In addition, (+)-sophoranol (4) exhibited moderate inhibition on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 264.7 macrophages with IC50 value of 22.14 μM, while lupanine (17) was found to inhibit the growth of human glioma stem cells GSC-3# at 20 μg/mL. PMID: 32924588 [PubMed - as supplied by publisher]
Source: Natural Product Research - Category: Biochemistry Authors: Tags: Nat Prod Res Source Type: research