Autophagy Controls Mesenchymal Stem Cell Therapy in Psychological Stress Colitis Mice.

In this study we show that psychological stress attenuates therapeutic effects of MSCT in a DSS-induced colitis mouse model by elevating the levels of exosomal Mir7k/mmu-let-7k (microRNA 7k) in circulation. Mechanistically, Mir7k inhibits STAT3 pathway in donor MSCs, leading to upregulated expression of BECN1 (beclin 1, autophagy related) and, thus, activation of macroautophagy/autophagy. Inhibition of autophagy by blocking Mir7k or activating STAT3 signaling can restore MSCT-mediated therapy in psychologically stressed colitis mice. Our study identifies a previously unknown role of autophagy in regulating MSCT therapy via exosomal miRNA Mir7k.
PMID: 32910719 [PubMed - as supplied by publisher]

Source: Autophagy - September 9, 2020 Category: Cytology Authors: Tian J, Kou X, Wang R, Jing H, Chen C, Tang J, Mao X, Zhao B, Wei X, Shi S Tags: Autophagy Source Type: research