Viruses, Vol. 12, Pages 1013: Infection Dynamics of Swine Influenza Virus in a Danish Pig Herd Reveals Recurrent Infections with Different Variants of the H1N2 Swine Influenza A Virus Subtype
Viruses, Vol. 12, Pages 1013: Infection Dynamics of Swine Influenza Virus in a Danish Pig Herd Reveals Recurrent Infections with Different Variants of the H1N2 Swine Influenza A Virus Subtype
Viruses doi: 10.3390/v12091013
Authors:
Tarka Raj Bhatta
Pia Ryt-Hansen
Jens Peter Nielsen
Lars Erik Larsen
Inge Larsen
Anthony Chamings
Nicole B. Goecke
Soren Alexandersen
Influenza A virus (IAV) in swine, so-called swine influenza A virus (swIAV), causes respiratory illness in pigs around the globe. In Danish pig herds, a H1N2 subtype named H1N2dk is one of the main circulating swIAV. In this cohort study, the infection dynamic of swIAV was evaluated in a Danish pig herd by sampling and PCR testing of pigs from two weeks of age until slaughter at 22 weeks of age. In addition, next generation sequencing (NGS) was used to identify and characterize the complete genome of swIAV circulating in the herd, and to examine the antigenic variability in the antigenic sites of the virus hemagglutinin (HA) and neuraminidase (NA) proteins. Overall, 76.6% of the pigs became PCR positive for swIAV during the study, with the highest prevalence at four weeks of age. Detailed analysis of the virus sequences obtained showed that the majority of mutations occurred at antigenic sites in the HA and NA proteins of the virus. At least two different H1N2 variants were found to be circulating in the herd; one H1N2 variant was circulating at the sow and nursery sites, while another H1N2 varia...
Source: Viruses - Category: Virology Authors: Tarka Raj Bhatta Pia Ryt-Hansen Jens Peter Nielsen Lars Erik Larsen Inge Larsen Anthony Chamings Nicole B. Goecke Soren Alexandersen Tags: Article Source Type: research
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