Proposed guidelines likely to identify more early lung cancers

Lung cancer is the second most prevalent cancer in the US, and the deadliest cancer killer. In 2020, an estimated 135,720 people will die from the disease — more than breast, colon, and prostate cancers combined. I’ll never forget meeting new, advanced-stage lung cancer patients who ask if their diagnosis could have somehow been made earlier, when treatment would have been more likely to succeed. In 2009, when I began practicing thoracic oncology, there were no approved screening tests for lung cancer. A brief history of lung cancer screening Hope for early detection and death prevention came in 2011 with the publication of the National Lung Screening Trial (NLST). This was the first randomized clinical trial to show a lung cancer mortality benefit for lung screening, using annual low-dose computed tomography (LDCT) scans for older patients with a significant smoking history. This led to the 2014 US Preventive Services Task Force (USPSTF) recommendation for lung cancer screening. The USPSTF recommended a yearly LDCT scan to screen people who met certain criteria: a 30-pack-year smoking history (smoking one pack of cigarettes per day for 30 years or the equivalent amount); being a current smoker or former smoker who quit within the past 15 years; and age from 55 to 80 years. Since the NLST publication, an additional randomized clinical trial done in Europe (the NELSON trial, published in the New England Journal of Medicine in February 2020) also showed a reduction ...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Cancer Lung disease Screening Source Type: blogs

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Authors: Chen P, Wang H, Li M, Yang L, Mou F, Singh B, He JY, Zhang W Abstract 6,12-Diphenyl-3,9-diazatetraasterane-1, 5, 7, 11-tetracarboxylate (DDTC) has been synthesized by the photodimerization of 4-phenyl-1,4-dihydropyridine-3,5-dicarboxylate. The potential of theercvantitumor activity and mechanism were investigated in vitro using MTT assay in human lung cancer cell line A549, ovarian cancer cell lines SKOV3 and A2780, breast cancer cell line MCF-7, gastric cancer cell line BGC-823, colon cancer cell line HT29, prostate cancer cell line DU145, and liver cancer cell line SMMC7721. The results show that DDTC ca...
Source: Disease Markers - Category: Laboratory Medicine Tags: Dis Markers Source Type: research
Einstein once said, “The world is not dangerous because of those who do harm but because of those who look at it without doing anything.” Low dose computed tomography for lung cancer screening (LCS) should be considered in the context of this statement. Despite the National Lung Screening Trial (NLST) and Dutch-Bel gian Lung Cancer Screening trial, which clearly demonstrate a reduction in lung cancer mortality, LCS rates of eligible patients fall well below those of other common cancers such as breast, colon, cervical, and prostate cancer.
Source: The Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Commentary Source Type: research
CD276 (also called B7-H3) is a pan-cancer antigen expressed in multiple solid tumors and an emerging cancer target. CD276 protein is overexpressed in pancreatic cancer, prostate cancer, breast cancer, colon cancer, lung cancer, and brain tumors (such as neuroblastoma) – making it an ideal target for cancer therapy. Investigators at the National Cancer Institute (NCI) have isolated a panel of anti-CD276 single domain antibodies (also known as nanobodies) from novel camel and rabbit single domain (VHH) libraries by phage display.  Nanobodies are the smallest known antigen-binding fragments of antibodies. Due ...
Source: NIH OTT Licensing Opportunities - Category: Research Authors: Source Type: research
AbstractObjectivesTetrandrine, a natural bisbenzylisoquinoline alkaloid, possesses promising anticancer activities on diverse tumours. This review provides systematically organized information on cancers of tetrandrinein vivo andin vitro, discuss the related molecular mechanisms and put forward some new insights for the future investigations.Key findingsAnticancer activities of tetrandrine have been reported comprehensively, including lung cancer, colon cancer, bladder cancer, prostate cancer, ovarian cancer, gastric cancer, breast cancer, pancreatic cancer, cervical cancer and liver cancer. The potential molecular mechani...
Source: Journal of Pharmacy and Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Review Source Type: research
Lung cancer is the most commonly diagnosed cancer worldwide, affecting more than 14 million people annually [1]. Every year, lung cancer causes more than 1.6 million deaths, which is greater than breast, colon and prostate cancers combined [2]. Similarly, in the UK, lung cancer is diagnosed in in excess of 46,000 people each year and is the leading cause of cancer related death [3]. Smoking is the primary cause of lung cancer in more than 80% of patients [4]. The incidence of lung cancer has fallen in the UK in the last 10 years, owing primarily to the reduction in male smoking, while the incidence of female lung cancer has risen.
Source: Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research
Design, Synthesis and Bioevaluation of Two Series of 3-((1-Benzyl-1H-1,2,3-triazol-4-yl)methyl)quinazolin-4(3H)-ones and N-(1-benzylpiperidin-4-yl)quinazolin-4-amines. Chem Biodivers. 2020 May 01;: Authors: Lan TT, Anh DT, Pham-The H, Dung DTM, Park EJ, Jang SD, Kwon JH, Kang JS, Thuan NT, Han SB, Nam NH Abstract Two series of 3-((1-benzyl-1 H -1,2,3-triazol-4-yl)methyl)quinazolin-4(3H)-ones ( 4a-j ) and N-(1-benzylpiperidin-4-yl)quinazolin-4-amines ( 6a-j ) were designed initially as potential acetylcholine esterase inhibitors. Biological evaluation demonstrated that series 6a-j significantly in...
Source: Chemistry and Biodiversity - Category: Biochemistry Authors: Tags: Chem Biodivers Source Type: research
Conclusion: The results of the present study demonstrate that ERC22 Lys751Gln polymorphisms may be associated with the development of colon and prostate cancers in the Turkish population. This was a small-scale study, and the results should be corroborated with further research including larger groups of patients with each cancer type and more healthy controls. PMID: 32277685 [PubMed - as supplied by publisher]
Source: Journal of B.U.ON. - Category: Cancer & Oncology Tags: J BUON Source Type: research
Abstract In our search for novel small molecules activating procaspase-3, we have designed and synthesized a series of novel acetohydrazides incorporating both 2-oxoindoline and 4-oxoquinazoline scaffolds (5a-t). Biological evaluation showed that a number of these acetohydrazides were comparably or even more cytotoxic against three human cancer cell lines (SW620, colon cancer; PC-3, prostate cancer; NCI-H23, lung cancer) in comparison to PAC-1, a first procaspase-3 activating compound, which was used as a positive control. Compound 5k activated the caspase-3 activity in U937 human lymphoma cells by 5-fold higher t...
Source: Chemistry and Biodiversity - Category: Biochemistry Authors: Tags: Chem Biodivers Source Type: research
CONCLUSIONS: These preliminary results demonstrate the success of a Military Treatment Facility (MTF)-based LCS Program in the detection of early stage lung cancer. Earlier stage detection may result in better health outcomes for affected patients. In the population studied, duration of smoking proved to be more significant than pack-years in predicting lung cancer risk. These results validate the newly dedicated resources and continued efforts to strengthen the LCS program at NMCSD and across MTFs. PMID: 31925432 [PubMed - as supplied by publisher]
Source: Military Medicine - Category: International Medicine & Public Health Tags: Mil Med Source Type: research
Breakthrough treatments for lung cancer and melanoma have driven down cancer mortality overall — and from 2016 to 2017 spurred the largest-ever decline.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Cancer Smoking and Tobacco Lung Cancer Colon and Colorectal Cancer Breast Cancer Cervical Cancer Prostate Cancer Obesity American Cancer Society your-feed-healthcare Source Type: news
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