CHD8 dosage regulates transcription in pluripotency and early murine neural differentiation [Genetics]

The chromatin remodeler CHD8 is among the most frequently mutated genes in autism spectrum disorder (ASD). CHD8 has a dosage-sensitive role in ASD, but when and how it becomes critical to human social function is unclear. Here, we conducted genomic analyses of heterozygous and homozygous Chd8 mouse embryonic stem cells...

Source: Proceedings of the National Academy of Sciences - September 7, 2020 Category: Science Authors: Sabina Sood, Christopher M. Weber, H. Courtney Hodges, Andrey Krokhotin, Aryaman Shalizi, Gerald R. Crabtree Tags: Biological Sciences Source Type: research