Age-related loss of neural stem cell O-GlcNAc promotes a glial fate switch through STAT3 activation [Cell Biology]
Increased neural stem cell (NSC) quiescence is a major determinant of age-related regenerative decline in the adult hippocampus. However, a coextensive model has been proposed in which division-coupled conversion of NSCs into differentiated astrocytes restrict the stem cell pool with age. Here we report that age-related loss of the posttranslational...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Charles W. White III, Xuelai Fan, Jason C. Maynard, Elizabeth G. Wheatley, Gregor Bieri, Julien Couthouis, Alma L. Burlingame, Saul A. Villeda Tags: Biological Sciences Source Type: research