Ligand-induced gene activation is associated with oxidative genome damage whose repair is required for transcription [Cell Biology]

Among several reversible epigenetic changes occurring during transcriptional activation, only demethylation of histones and cytosine-phosphate-guanines (CpGs) in gene promoters and other regulatory regions by specific demethylase(s) generates reactive oxygen species (ROS), which oxidize DNA and other cellular components. Here, we show induction of oxidized bases and single-strand breaks (SSBs), but...

Source: Proceedings of the National Academy of Sciences - September 7, 2020 Category: Science Authors: Shiladitya Sengupta, Haibo Wang, Chunying Yang, Bartosz Szczesny, Muralidhar L. Hegde, Sankar Mitra Tags: Biological Sciences Source Type: research