Neuromedin U: potential roles in immunity and inflammation.

Neuromedin U: potential roles in immunity and inflammation.
Immunology. 2020 Sep 05;:
Authors: Ye Y, Liang Z, Xue L
Abstract
Since the discovery of Neuromedin U (NmU) from porcine spinal cord in 1985, this neuropeptide has been subsequently identified in many other species with multiple physiological and pathophysiological roles detected, ranging from smooth muscle contraction, feeding, energy balance to tumorigenesis. Intriguingly, NmU is also emerging to play pro-inflammatory roles involving immune cell activation and cytokine release in a neuron-dependent or neuron-independent manner. The NmU-mediated inflammatory responses have already been observed in worm infection, sepsis, autoimmune arthritis and allergic animal models. In this review, we focus on the roles of NmU in immunity and inflammation by highlighting the interactions between NmU and immune cells, summarising the signalling mechanism involved in their reactions, and discussing its potential contributions to inflammatory diseases.
PMID: 32888314 [PubMed - as supplied by publisher]

Source: Immunology - September 4, 2020 Category: Allergy & Immunology Authors: Ye Y, Liang Z, Xue L Tags: Immunology Source Type: research