Bone mineral density and fracture risk in adult patients with hypophosphatasia

ConclusionBMD in adult HPP patients is not systematically reduced. Conversely, increased lumbar spine BMD appears to be associated with severely compromised mineralization and increased risk for HPP-related fractures while BMD at the hip appears unaffected by indicators of disease severity, suggesting suitability of this anatomic location for assessing and discerning disorders with increased fracture risk owing to reduced BMD like osteoporosis.Trial registration numberGerman register for clinical studies (DRKS00014022)Date of registration02/10/2018 – retrospectively registered
Source: Osteoporosis International - Category: Orthopaedics Source Type: research