Methadone is an option to treat cancer pain in carefully selected patients

AbstractMethadone ’s pharmacological properties and its numerous routes of administration can make it a useful analgesic option in adults and children with cancer pain. However, careful patient selection and monitoring is needed, especially if methadone is co-administered with agents that induce or inhibit hepatic CYP enzymes, and/or prolong the QTc interval. Prescribing methadone in either opioid-naïve, especially elderly, patients or those switching from other opiates requires a conservative approach to dosage.
Source: Drugs and Therapy Perspectives - Category: Drugs & Pharmacology Source Type: research