Biomechanics of Diastolic Dysfunction: a 1D Computational Modelling Approach.

In this study, we have developed a computational model of DD by leveraging the power of an advanced one-dimensional (1D) arterial network coupled to a four-chambered 0D cardiac model. The two main pathologies investigated were linked to the active relaxation of the myocardium and the passive stiffness of the left ventricular wall. These pathologies were quantified through two parameters for the biphasic delay of active relaxation, which simulate the early and late phase relaxation delay, and one parameter for passive stiffness, which simulates the increased non-linear stiffness of the ventricular wall. A parameter sensitivity analysis was conducted on each of the three parameters to investigate their effect in isolation. The three parameters were then concurrently adjusted to produce the three main phenotypes of DD. It was found that the Impaired Relaxation (IR) phenotype can be replicated by mainly manipulating the active relaxation, the Pseudo-Normal (PN) phenotype was replicated by manipulating both the active relaxation and passive stiffness, and, finally, the Restricted (R) phenotype was replicated by mainly changing the passive stiffness. This paper presents a simple model producing a holistic and comprehensive replication of the main DD phenotypes and presents novel biomechanical insights on how key parameters defining the relaxation and stiffness properties of the myocardium affect the development and manifestation of DD. PMID: 32822212 [PubMed - as supplied b...
Source: American Journal of Physiology. Heart and Circulatory Physiology - Category: Physiology Authors: Tags: Am J Physiol Heart Circ Physiol Source Type: research