Role of Extracellular Vesicles in Pulmonary Arterial Hypertension: Modulation of Pulmonary Endothelial Function and Angiogenesis.

CONCLUSIONS: Patients with PAH have higher levels of EVs harboring increased amounts of angiogenic proteins, which induce activation of hPAECs and in vitro angiogenesis. These effects were partly because of platelet-derived EVs evasion of lysosomes upon internalization within hPAEC and through possible involvement of P-selectin-PSGL-1 pathway.
PMID: 32757648 [PubMed - as supplied by publisher]

Source: Arteriosclerosis, Thrombosis and Vascular Biology - August 5, 2020 Category: Cardiology Authors: Khandagale A, Åberg M, Wikström G, Lind SB, Shevchenko G, Björklund E, Siegbahn A, Christersson C Tags: Arterioscler Thromb Vasc Biol Source Type: research