HIF-1 α-mediated TERT Activation Inducing Autophagy through mTOR Promotes Papillary Thyroid Carcinoma Progression During Hypoxia Stress.

Conclusions We identified a novel molecular mechanism involving the HIF-1α/TERT axis, which promoted PTC progression by inducing autophagy through mTOR during hypoxia stress. These findings may provide a basis for the new treatment of aggressive PTCs. PMID: 32772829 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research