Cancers, Vol. 12, Pages 2201: High-Risk Human Papillomavirus and Tobacco Smoke Interactions in Epithelial Carcinogenesis

Cancers, Vol. 12, Pages 2201: High-Risk Human Papillomavirus and Tobacco Smoke Interactions in Epithelial Carcinogenesis Cancers doi: 10.3390/cancers12082201 Authors: Francisco Aguayo Juan P. Muñoz Francisco Perez-Dominguez Diego Carrillo-Beltrán Carolina Oliva Gloria M. Calaf Rances Blanco Daniela Nuñez-Acurio Cervical, anogenital, and some head and neck cancers (HNC) are etiologically associated with high-risk human papillomavirus (HR-HPV) infection, even though additional cofactors are necessary. Epidemiological studies have established that tobacco smoke (TS) is a cofactor for cervical carcinogenesis because women who smoke are more susceptible to cervical cancer when compared to non-smokers. Even though such a relationship has not been established in HPV-related HNC, a group of HPV positive patients with this malignancy are smokers. TS is a complex mixture of more than 4500 chemical compounds and approximately 60 of them show oncogenic properties such as benzo[α]pyrene (BaP) and nitrosamines, among others. Some of these compounds have been evaluated for carcinogenesis through experimental settings in collaboration with HR-HPV. Here, we conducted a comprehensive review of the suggested molecular mechanisms involved in cooperation with both HR-HPV and TS for epithelial carcinogenesis. Furthermore, we propose interaction models in which TS collaborates with HR-HPV to promote epithelial cancer initiation, promotion, and progression. Mor...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research