Exploring imaging features of molecular subtypes of large cell neuroendocrine carcinoma (LCNEC)

Large cell neuroendocrine carcinoma (LCNEC) of the lung is a rare tumor type, representing 1-3% of all types of lung cancer [1,2]. The histological diagnosis of LCNEC is complex, and preferably, surgical resected tumor tissue is used [3]. LCNEC can be separated in two main molecular subtypes: the first is SCLC-like (pathological SCLC-like, pSCLC-like), with co-mutation of RB1 and TP53 and loss of immunohistochemical (IHC) pRb expression and the second is NSCLC-like (pNSCLC-like), with co-mutation of TP53 and STK11/KEAP1/KRAS genes and preserved pRb expression [4 –6].

Source: Lung Cancer - August 10, 2020 Category: Cancer & Oncology Authors: B.C.M. Hermans, S. Sanduleanu, J.L. Derks, H. Woodruff, L. Hillen, R. Casale, F. Mohamed Hoesein, E. de Jong, D.M.H.J. ten Berge, E.J.M. Speel, P. Lambin, H.A. Gietema, A-M.C. Dingemans Source Type: research