Endothelial Cell Density Changes in the Corneal Center Versus Paracentral Areas After Descemet Membrane Endothelial Keratoplasty

Purpose: To analyze whether endothelial cell density (ECD) differs between central and paracentral areas after Descemet membrane endothelial keratoplasty (DMEK) and to identify the locations of the highest and lowest ECD. Methods: In this retrospective cohort study, central and paracentral ECDs of 30 eyes of 30 patients who underwent DMEK for Fuchs endothelial corneal dystrophy were evaluated. Central, superonasal, superotemporal, and inferior specular microscopic images were analyzed at 1, 3, 6, 9, and 12 months after DMEK. Changes in ECD by location and over time and changes in location for the highest and lowest ECD were evaluated. Results: When compared with the preoperative donor ECD, the central ECD decreased by 32 (±11)% at 12 months postoperatively. ECD decline between 1 and 12 months postoperatively in the central, inferior, superonasal, and superotemporal location were 7%, 12%, 16%, and 13%, respectively (P
Source: Cornea - Category: Opthalmology Tags: Clinical Science Source Type: research

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AbstractPurpose of ReviewDescemet membrane endothelial keratoplasty (DMEK) has become the treatment of choice for endothelial diseases such as Fuchs endothelial corneal dystrophy (FECD), especially in the United States and Europe. In this review, we give an overview of current knowledge about DMEK in Asian eyes and describe novel surgical modifications of this technique for these cases.Recent FindingsAlthough many scientific reviews about DMEK in Caucasian eyes have already been published, there is still little knowledge about clinical outcomes of DMEK in Asian eyes. This is of particular importance, as there are substanti...
Source: Current Ophthalmology Reports - Category: Opthalmology Source Type: research
Conclusions: DSAEK inherently results in higher total stromal backscattering (haze) compared with DMEK because of the addition of stromal tissue. Lower higher order aberrations of the posterior cornea and lower total stromal backscattering (haze) may both contribute to superior visual outcomes after DMEK compared with DSAEK.
Source: Cornea - Category: Opthalmology Tags: Clinical Science Source Type: research
Conclusions: The presence of graft detachment after DMEK increases the risk of graft detachment in subsequent DMEK in the contralateral eye. Modification in perioperative care and surgical technique in the contralateral eye, such as a larger gas bubble, use of SF6 20%, and combining cataract surgery, may be needed when graft detachment occurs after DMEK in the first eye.
Source: Cornea - Category: Opthalmology Tags: Clinical Science Source Type: research
ConclusionsCorneal transplantation in Ireland is following international trends as endothelial procedures have become the most common approach since 2018. However, a low overall number of transplants is performed in Ireland compared with other countries suggesting that care pathways should be implemented to improve access to corneal transplantation.
Source: Irish Journal of Medical Science - Category: General Medicine Source Type: research
Conditions:   Cystoid Macular Edema;   Fuchs Dystrophy Intervention:   Diagnostic Test: Optical Coherence Tomography Sponsor:   Wake Forest University Health Sciences Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusion: The indications for corneal transplantations changed with time in Taiwan. Regraft was the leading indication, but there was a decreasing trend over time. The proportion of bullous keratopathy increased significantly over the past decade and is the second most common indication, similar to the most developed countries. Both corneal scar and opacity, and keratitis showed a decreasing trend of occurrence compared with a previous study in Taiwan. The proportion of keratoconus remained low, making it the least common indication for corneal transplantation.
Source: Eye and Contact Lens: Science and Clinical Practice - Category: Opthalmology Tags: Article Source Type: research
An 80-year-old male was referred to our hospital for chronic bullous keratopathy in the right eye. Ten years before, he was affected by an attack of primary acute angle closure glaucoma in high hyperopia and Fuchs ’ endothelial dystrophy. A bilateral iridotomy was performed. Thereafter, the patient developed an endothelial decompensation in the left eye, and, in another hospital, he underwent an open-sky combined cataract extraction and penetrating keratoplasty. Our surgical approach for the right eye consi sted of phacoemulsification and, after 1 month, a Descemet’s stripping automated endothelial keratoplasty...
Source: Case Reports in Ophthalmology - Category: Opthalmology Source Type: research
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