Neoflavonoids from the heartwood of Dalbergia melanoxylon.

Neoflavonoids from the heartwood of Dalbergia melanoxylon.
Nat Prod Res. 2020 Aug 03;:1-7
Authors: Wang MF, Ma GQ, Shao F, Liu RH, Chen LY, Liu Y, Yang L, Meng XW
Abstract
Three new neoflavonoids, named (1S,8R,9S)-1,5-dihydroxy-4,12-dimethoxy-8-vinyl-tricyclo[7.3.1.02,7]trideca-2,4,6,11-tetraen-10-one (1), 2,5,2',5'-tetrahydroxy-4-methoxybenzophenone (2) and 2,5,3'-trihydroxy-4-methoxybenzophenone (3), were isolated from the heartwood of Dalbergia melanoxylon. Their structures were established by spectroscopic methods, including UV, IR, HRMS, 1 D and 2 D-NMR. Compounds 1-3 were evaluated for inhibitory activity against three fungal strains Candida albicans, Mucor ramosissimus, Saccharomycopsis fermentans and seven bacterial strains Shigella dysenteriae, Salmonella enteri, Bacillus cereus, Staphylococcus epidermidis, Bacillus sphaericus, Staphylococcus aureus, Escherichia coli using the broth dilution method. However, none of compounds 1-3 showed potential antimicrobial activities in vitro.
PMID: 32744091 [PubMed - as supplied by publisher]

Source: Natural Product Research - August 2, 2020 Category: Biochemistry Authors: Wang MF, Ma GQ, Shao F, Liu RH, Chen LY, Liu Y, Yang L, Meng XW Tags: Nat Prod Res Source Type: research