Evaluation of chronic toxicity of cyclocreatine, a creatine analog, in Sprague Dawley rat after oral gavage administration for up to 26 weeks.

In conclusion, chronic administration of cyclocreatine by oral gavage in Sprague Dawley rats induced the seizures and microscopic lesions in the brain, testes and thyroid. Based on the results of this study the highest tested dose of 600 mg/kg/day (mean Cmax of 151.5 μg/mL; AUC0-24 of 1970 h*μg/mL) was considered the maximum tolerated dose (MTD) in SD rats. PMID: 32745584 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32745584?dopt=Abstract

Source: Regulatory Toxicology and Pharmacology : RTP - July 30, 2020 Category: Toxicology Authors: Kale VP, Wallery J, Novak J, Gibbs S, Bourdi M, Do MT, McKew JC, Terse PS Tags: Regul Toxicol Pharmacol Source Type: research